Ageing is a triumph of the contemporary society but also represents a great challenge for the coming generations. Although the life expectancy has grown significantly in the last century, healthy life expectancy, i.e., the number of years spent free of disabilities, has grown much slower than life expectancy. Reducing the gap between healthy life expectancy and life expectancy offers enormous potential not only for individual health and wellbeing but also for economic growth. Recent progress in understanding the biology of ageing suggests that designing interventions that are able to reduce gaps in healthy life expectancy becomes now also technically feasible. In my presentation I will discuss our work in the use of stem cells to create ageing models in order to identify new molecular targets and drugs to slow down ageing processes. In addition, I will discuss formulations that might be able to reduce the impact of biological ageing